Reiter's Syndrome

Reiter's syndrome, also called "reactive arthritis," is a form of arthritis that, in addition to joints, also affects many other areas of the body including the eyes, urethra (the tube that carries urine from the bladder to the outside of the body) and skin.

The disease is recognized by a number of symptoms in different organs of the body that may or may not appear at the same time. It may come on quickly and severely or more slowly, with sudden remissions or recurrences.

Reiter's syndrome primarily affects sexually active males between the ages of 20 and 40. Those with HIV (human immunodeficiency virus) are at a particularly high risk.

What Causes Reiter's Syndrome?

The cause of Reiter's syndrome is still unknown, but research suggests the disease is caused by a combination of genetic predisposition and various other factors.

Approximately 75% of those with the condition have a positive blood test for the genetic marker HLA-B27, which suggests that the disease has a genetic component. In sexually active males, most cases of Reiter's syndrome follow infection with Chlamydia trachomatis or Ureaplasma urealyticum (both are common sexually transmitted diseases). In other cases, people develop the symptoms following an intestinal infection with Shigella, Salmonella, Yersinia or Campylobacter bacteria that cause food poisoning.

With the exception of using condoms during sexual activity, there is no known preventative measure for Reiter's syndrome.

What Are the Symptoms of Reiter's Syndrome?

The first symptoms of Reiter's syndrome are painful urination and a discharge from the penis if there is inflammation of the urethra. More rarely diarrhea occurs if the intestines are affected. This is then followed by arthritis 4 to 28 days later. The arthritis usually affects the fingers, toes, ankles, hips and knee joints. Other symptoms include:

• Mouth ulcers
• Inflammation of the eye
• Keratoderma blennorrhagica (patches of scaly skin on the palms, soles, trunk, or scalp)

How Is Reiter's Syndrome Diagnosed?

Diagnosis of Reiter's syndrome can be complicated by the fact that symptoms often occur several weeks apart. A doctor may diagnose Reiter's syndrome when the patient's arthritis occurs together with or shortly following inflammation of the eye and the urinary tract and lasts a month or longer.

There is no specific test for diagnosing Reiter's syndrome, but the doctor may have the urethral discharge tested to check for sexually transmitted diseases. Stool samples may also be tested for signs of infection. Blood tests of Reiter's syndrome patients are typically positive for the HLA-B27 genetic marker, with an elevated white blood cell count and an increased erythrocyte sedimentation rate (ESR) -- both signs of inflammation. The patient may also be mildly anemic (having too few red blood cells in the bloodstream, leading to inadequate oxygen in the organs and tissues).

X-rays do not usually reveal any abnormalities unless the patient has had recurrent episodes of the disease. On an X-ray, joints that have been repeatedly inflamed may show areas of bone loss, signs of osteoporosis, or bony spurs.

How Is Reiter's Syndrome Treated?

Bacterial infections, such as Chlamydia, will need to be treated with antibiotics. Joint inflammation is usually treated with nonsteroidal anti-inflammatory drugs (NSAIDs). Skin eruptions and eye inflammation can be treated with steroids.

Those with chronic disease may be prescribed other medications including methotrexate. Patients with chronic arthritis also may be referred to a physical therapist and may be advised to exercise regularly.

What Is the Outlook For People With Reiter's Syndrome?

The prognosis for Reiter's syndrome varies. Most people recover in 3 to 4 months, but about half have recurrences for several years. Some people develop complications that may include inflammation of the heart muscle, inflammation with stiffening of the spine, glaucoma, progressive blindness, feet abnormalities or accumulation of fluid in the lungs.